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Day -20: Campath Poster-Baby

/ Evan / 4 Comments

The evening went well, Zoe slept very fitfully through the night. We saw a little bit of rash again this morning just as she was getting her Hydrocortisone pre-med, which may have been coincidence since Hydrocortisone usually treats rashes, not causes them.

We’re told Zoe is looking more and more like a “Poster-baby” for

Lucky the fish

Campath, her reactions so far are the mildest most of the staff have seen. I’ll take it.

Today is expected to go just the same as yesterday, no changes to treatment. If we finish out the week tomorrow without anything else eventful, we can breath a big sigh of relief for our first successful week.

Morning Counts:

  • Creatinine: .2 (down from yesterday, which is good)
  • Bilirubin: .3 (unchanged)
  • AST: 78
  • ALT: 36
  • Sodium: 141
  • WBC: 11.5
  • RBC: 3.38
  • Hemo: 10.2
  • Platelets: 111 (down from the campath, we may hold her hydroyurea if they get too low)
  • Lymphocytes: 0

Very quiet today so far. Our appointed mascot, Lucky the fish, highly approves.

Afternoon Update:

Once again, we made it all the way to the end of the day before seeing any reactions. Zoe is having a bit of a flush this time, in what you might call an unusual pattern. Her entire left side of her face is red, with a line right down the middle where it ends.

A couple of NP’s came in to take a look, and they hadn’t seen a rash quite like this before. But, it doesn’t appear to be bothering Zoe much, she’s a little squirmy but vitals are fine.

This reaction is definitely curious. I promise we didn’t leave her in a tanning bed on one side too long, but that sure is what it looks like.

Still, one of the NP’s said he’d never seen such a happy Campath baby, so I guess all things considered we’re doing ok.

Late update: It’s called Harlequin Phenomenon, and we’re told it’s harmless.

Day -21: Campath Full Dose

/ Evan / 3 Comments

Our second day of conditioning brings the first full dose of Campath, and a much higher chance of a reaction. So far this morning we’ve done her pre-meds with the addition of Dexamethasone as the steroid, and begun her Campath. The chemo is still administered on a stepped schedule, a small dose, then a slightly higher dose, then the full amount for the remainder of the day.

Zoe’s counts look good:

  • WBC: 18.2 (higher)
  • Hemo: 9.9
  • Lymphocytes: 1 (her partial dose almost completely wiped them out — this is intended)
  • Sodium: 138
  • Creatinine: .3 (up from yesterday, we’re told it will go up and down with the conditioning)
  • Platelet: 331
  • Bilirubin: .4 (still fine)
  • AST: 44
  • ALT: 21

So, no major changes other than a drop in platelets and lymphocytes, both expected. I’ll update later with any reactions and changes, she has only just begun the Campath so it’s calm at the moment.

Afternoon Update:

Everything has gone really smoothly again today.

Minor Campath Rash

Around 3pm, Zoe started some minor rashes on her face and head, no where else. She’s been very sleepy and calm all day and we were beginning to think she would plow on through day 2 without any side effects. So far, things have gone much better than we expected.

We finished the Campath and her rashes showed up just as we began the saline flush, exactly the same as yesterday’s slight fever. Nothing to be concerned about, Zoe is doing great with her treatment at this point.

Blood pressure has held steady around 100/65 most of the day, temperature averaging about 98 degrees.

So far, so good.