Cyclosporine & Sodium, Updates

It’s Monday and we’re back to the day hospital at Duke. Today was blood draws and a redo of the GFR kidney function test.

On Friday they took a Cyclosporine level and it was really high, 590 or so, which is much too high for Zoe. It’s a bit of a mystery, since we haven’t changed her dose and, after much hand wringing, feel sure that nothing happened to give her too much. We just don’t know how it could be that high. Normal therapeutic range is 150-250.

She did get a dose just before the test was taken, and we’ve seen in the past that that can amp the results up considerably. We got a reading in the 400’s awhile back after she had a dose just before the test, but 590 is just very high.

So, she’s off Cyclosporine, probably for good now since it is not a part of her conditioning regimen.

We retested some levels today along with the GFR, and found that it was still at a therapeutic level, 112, despite being discontinued days ago. Her GFR was not improved, still about 50 (100 is what we want), but the feeling is that the continued presence of Cyclosporine is keeping it down.

On a positive note, her Sodium has gone up to 137. It’s been down throughout her entire treatment, ever since she began her chemo, but we did no have a reason for it. It would now appear that the Cyclosporine was causing low Sodium for Zoe for some reason.

This doesn’t change much for us, we still proceed ahead, but we’ll be monitoring her kidneys via other markers as we go.

Tomorrow is another spinal tap and bone marrow aspiration, another meeting with the transplant team, then home for the week we hope.

One thought on “Cyclosporine & Sodium, Updates

  1. I apologize for not logging in for a while and am sorry I didn’t know you were in Durham! It sounds like you may be going back to Win-Salem today? We’ll be out of town next weekend, but after that will be around until late July-early August. I would love to help out when you’re back at Duke in any way that might be useful. Please do call or write with any requests!

    Love & hugs, Jane

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